Effect of Ginger Extract on Lipid Profile and Liver Function in Uterine Fibroids Rats تأثير مستخلص الزنجبيل علي مستوى الدهون ووظائف الكبد في الفئران المصابة بالورم الليفي الرحمي

نوع المستند : بحوث نشر لدرجة الماجستير والدكتوراه

المؤلفون

1 باحثة بمرحلة الدكتوراة -قسم الاقتصاد المنزلي-كلية التربية النوعية-جامعة أسيوط-تخصص تغذية وعلوم الأطعمة

2 أستاذ علوم الأغذية المتفرغ-قسم الاقتصاد المنزلي- كلية التربية النوعية ، جامعة أسيوط

3 أستاذ مساعد علم وظائف الأعضاء- قسم علم الحيوان -كلية العلوم -جامعة الأزهر

4 مدرس التغذية وعلوم الأطعمة-قسم الاقتصاد المنزلي-كلية التربية النوعية-جامعة أسيوط

المستخلص

Uterine fibroids (UFs) are non-cancerous tumors of the uterus that often lead to significant health issues such as bleeding, pain, and infertility.Study aimed to evaluate the effects of ginger extract on the lipid profile and liver function in rats UF. Thirty adult female Wistar albino rats were divided into three groups: a negative control group, a UF group, and a UF group treated with ginger ethanolic extract (GEE) at a dose of 100 mg/kg/day for six weeks. The results showed that rats with uterine fibroids exhibited significant alterations. Serum total cholesterol (T.C) elevated (273.3±7.4 mg/dl), along with triglycerides (T.G)(245.8±16.9 mg/dl), and low-density lipoprotein (LDL)(186.3±10 mg/dl), while high-density lipoprotein (HDL) levels were significantly decreased (37.3±1.02 mg/dl). Moreover, glucose levels were elevated (181.4±40.3 mg/dl), indicating metabolic dysfunction. In terms of liver function, there was a notable increase in liver enzyme activities: alanine aminotransferase (ALT)(74.2±7.11 U/L), aspartate aminotransferase (AST)(98.8±8.6 U/L), alkaline phosphatase (ALP)(164.4±7.4 U/L), and gamma-glutamyl transferase (GGT)(14.6±1.7 U/L), suggesting liver damage and dysfunction. Treatment with GEE (100 mg/kg/day) led to significant improvements in these parameters. Serum T.C was reduced to (127.7±6.6 mg/dl), T.G to (120.6 ±15 mg/dl), and glucose to (102.9 ± 0.7 mg/dl). Furthermore, liver enzyme levels decreased significantly: ALT(40±3.3 U/L), AST(70.5±8.6 U/L), ALP(89 ±5.7 U/L), and GGT (7.5±0.6 U/L). These results indicate that ginger extract has a beneficial effect in managing lipid metabolism and liver function in uterine fibroid-induced rats, demonstrating its potential as a therapeutic.

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